Insight has been gained into Myc's function in normal physiology, where its role appears to be organ specific, and in cancer where many mechanisms contribute to aberrant Myc expression.
In addition, many damage mechanisms contribute to the crack growth process under TMF conditions.
The complexity of tissue- and day time-specific regulation of thousands of clock-controlled genes (CCGs) suggests that many regulatory mechanisms contribute to the transcriptional output of the circadian clock.
However, many other mechanisms contribute simultaneously to the MDR phenotype, which may affect drug absorption, distribution and metabolism, thus modulating the efficacy of chemotherapeutic agents consequently.
In addition, RPol II enrichment at the promoter region does not guarantee the expression of downstream gene; many mechanisms can contribute to such deviation, such as RPol II stalling, RNA binding protein-induced post-transcriptional regulation, and so on.
Many mechanisms can contribute to the undertreatment of CVD among people with bipolar disorder.
The many mechanisms that contribute to long-lasting synaptic plasticity have been reviewed extensively in recent years (Atwood et al. 2014; Kandel et al. 2014) and therefore will not be discussed in detail in this review.
There are many mechanisms that contribute to the anti-tumour activity of Cetuximab and Trastuzumab, including a direct inhibition of tyrosine kinase activity relating to the HER-family signal, the inhibition of cell cycle progression, and increased levels and activities of pro-apoptotic molecules (Sliwkowski et al, 1999; Cuello et al, 2001).
The co-ordinated activity of many different cellular and biochemical mechanisms contribute to the development of a hypoxia-tolerant phenotype.
Many mechanisms of EBI contribute to the pathogenesis of DCI and are hence accountable for the poor outcomes.
