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From a practical standpoint, there are many markers with unclear relationships to specific disease.
Many markers with the largest effects were either shared across traits or were within close proximity.
In CML patients, analysis of MDSC expansion is complicated by the fact that CML cells share many markers with MDSCs.
This property of the score ensures that the enrichment of a gene set is due to the simultaneous presence of many markers with association and not a few with strong association.
Therefore, if the phenotype is controlled by many markers with small effects, ridge regression will capture those effects (Heffner et al., 2009), whereas LASSO will capture large effects with a small number of markers.
We identified many markers with one or more clusters beyond the standard AA, BB, AB, and N clusters, suggesting OTVs also alter hybridization intensities on the Illumina platform sufficiently for the detection of VINOs (unpublished).
Similar(53)
These cells expressed many markers associated with stem cells and with decreased patient survival [ 26], including CD44+ and CD24−/low markers, and elevated EMT markers and properties.
This strategy allows for sorting with simultaneous staining with many markers.
While rare alleles are not in LD with many markers, common alleles are in high LD with many, not necessarily adjacent, markers.
In practise it might happen that this is not the case and some QTL are in LD with many markers (requires more smoothing) whereas others only with few markers (requires less smoothing).
Some SDRs in the latter case might be the result of genotyping error and could be removed for map construction, but a large SDR with many markers should be included in the map with special care.
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