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Many markers are first made in miniature, with precise scaled-down patterns to determine the optimum layout for minimal yardage; the optimal miniature marker is then used as the guide for making the full-scale cutting marker.
Moreover, this strategy would leave an erythromycin resistance marker in the genome for screening, which prevents it from manipulating multiple genes, since not many markers are available for Clostridia [21], [36], [39], [40], [41], [42], [43], [44].
Many markers are specific for layer 2 or 6 but not both.
In this series of increasingly denser models, we aim to discover how many markers are needed to increase the predictive ability.
Among other methods to measure effective population size, molecular approaches may constitute an interesting option, especially if many markers are available.
One major drawback of many of these methods is their computational cost, which is very significant when many markers are considered.
Similar(45)
Finally, many markers were related to G-protein signaling.
To asses MVD in tumors tissues many markers were used, that is, CD34, CD31, CD105, and von Willebrand factor [ 5– 7].
In the step estimating marker effects, the estimation of effects of very many markers is hampered by the LD, i.e. collinearity, between the marker effects.
In the past, genotyping of many markers was expensive, therefore, specific experimental designs were developed to reduce the impact of having fewer markers on statistical power [ 1].
Recently many markers were described in ovarian cancer diagnosis; however, in our opinion HE4 seems to be the most promising among them.
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CEO of Professional Science Editing for Scientists @ prosciediting.com