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As we require EFO to be cross-referenced to as many external functional genomics datasets as possible, we maximize interoperability and therefore add as many mappings to different ontologies as are valid for our given class and curate these.
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We consider the target figures and divisions given by TTD to be a good approximation (they include a proportion of authenticated one-to-many mappings) to a set of bona fide primary targets (i.e. where the interaction in vitro is mechanistically causative for the therapeutic effect in vivo).
While terminologies created from data suffice for many applications, mappings to standardized guidelines promote portability and help on quality control.
Indeed, the space is extended from a uniformly smooth and uniformly convex Banach space to a uniformly smooth and strictly convex Banach space; the mapping is extended from a pari of mappings to infinite many mappings.
On the other hand, depending on the evolutionary distance of the organisms providing the input pathways, it might be more meaningful do differentiate between the alignments yielding one-to-many mappings as opposed to those providing one-to-few mappings.
The random nature of the additive and convolutional noises results in one to many mappings between clean and noisy feature spaces and a given clean feature vector can generate different noisy vectors, and vice versa [3]. Figure 1 shows the effect of noise on the probability density function of clean speech when the noise is assumed stationary Gaussian noise [2].
Such one-to-many mappings possibly correspond to different optical conformations of the same metabolite.
Such one-to-many mappings possibly correspond to reactions that are lumped together in the systems biology model at hand.
Some large tRNA clusters that vary in gene number across species produced complex sets of many:many mappings, which are particularly hard to resolve into 1 1 ortholog annotations.
Specifically, 369 one-to-one mappings, 1,113 one-to-many mappings and 1,050 many-to-many mappings (M. barkeri to M. acetivorans) were generated.
However, the reported mapping quality often correlates weakly with actual accuracy and the qualities of many mappings are underestimated, encouraging the researchers to discard correct mappings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com