Sentence examples for many malignant cells from inspiring English sources

The most intense intranuclear staining of DAB4 was found within the nucleoli, which featured prominently in many malignant cells.

Many malignant cells overexpress so called multidrug resistant transmembrane proteins which are able to remove the drug from the cell using ATP-dependent active transporter mechanisms.

As many malignant cells grow more efficiently than normal cells when cultured in serum-deficient medium, we examined the abilities of the two transfected cell lines to grow in serum-deficient conditions (right panel).

Many malignant cells, however, have developed ways to subvert apoptosis, a characteristic that constitutes a major clinical problem.

Many malignant cells metabolize glucose via pyruvate preferentially to lactate instead to CO2 and H2O through mitochondrial oxidative metabolism even in the presence of oxygen.

Activation of wild-type p53 with the small molecule sirtuin inhibitor Tenovin-6 (Tnv-6) induces p53-dependent apoptosis in many malignant cells.

Inhibition of mTOR leads to G1 arrest of many malignant cell lines, and currently analogs of rapamycin are being investigated as cancer therapeutic agents [ 14, 15].

Recent studies have demonstrated that in many malignant cell lines derived from various carcinomas the level of RAR-β2 mRNA (one of four transcripts of this gene) is decreased or undetectable [ 7- 9].

Markedly elevated levels of hexokinase II have been described in many malignant cell lines and unlike normal tissue, 50 80% of the enzyme is bound to the mitochondrial fraction, where it is thought to have preferential access to intramitochondrially generated ATP and be more resistant to Glucose-6-PO4 inhibition (Arora and Pedersen, 1988; Arora et al, 1992).

The carbohydrate has a very simple structure: it is composed almost entirely of tetra- tri- and disaccharides having the general formula (NeuNac n leads to [Gal leads to GalNac] alpha leads to, where n = 0, 1 or 2. In many malignant cell lines, the antigen is produced constitutively in vitro; but in one that has been examined, its synthesis can be induced by high concentrations of lactate.

Although the initial clinical evaluation of CAR-T cells focused on B cell non-Hodgkin's lymphoma (B-NHL) (Kochenderfer et al., 2010; Till et al., 2008), the most striking outcomes have been obtained in B-ALL by targeting CD19, a B cell-lineage antigen expressed on the surface of normal B cells and many malignant B cells (Scheuermann and Racila, 1995; Depoil et al., 2008).