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Investigations of the transcriptome and the proteome of S. typhimurium slyA mutants have identified many loci with altered expression in slyA mutant strains [38], [39].
To examine whether the observed effects of heterozygosity on recruitment success can be explained by a few loci with strong effects, or many loci with small effects, we used logistic regression analyses to calculate the association between heterozygosity and recruitment success for each locus separately.
SNP arrays allow the identification of many loci with either LOH or amplification.
The heritable contribution to common polygenic disease remains challenging to resolve, but GWAS have now mapped many loci with high statistical confidence.
These studies have shown that in addition to major QTL with large effects, many loci with smaller effects contribute to phenotypic variation.
The genetic architecture of resistance to internal parasites is a complex trait that is influenced by many loci with small effects [ 21].
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Such a scenario could produce patterns of genome variation similar to what we found in Sashin Creek with many loci associated with migration/residency, many outlier loci from FST analysis, high LD, a largely negative departure from neutrality in the source population, and many private alleles being present in the migrants.
Despite the success in using genome-wide association studies to identify many loci associated with human disease, there are several gaps in understanding of how common genetic diseases are manifested.
GWA studies have identified many loci associated with plasma lipid and lipoprotein traits, including several not previously known to be related to lipoprotein metabolism [9], [10], [11][12].
Large-scale genome-wide association studies (GWAS) have identified many loci associated with body mass index (BMI), but few studies focused on obesity as a binary trait.
These results suggest that many loci associated with type 2 diabetes are commonly shared between European and Chinese populations.
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