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However, the adult OVX rabbit model has many limitations which preclude its use for routine drug screening, including limited availability of skeletally mature aged rabbits, requirements for surgical manipulation, long study duration and a large body weight that requires preparation of large quantities of agents.
Traditional engineering education at university level has many limitations which has prompted the growth of newer approaches.
The compilation had many limitations which have caused some observers to doubt that causality has been demonstrated.
However, there are many limitations which are directly related to the paucity of evidence and the lack of data.
Researchers should be aware that while ecological momentary assessment offers many benefits, it simultaneously imposes many limitations which should be considered when studying physical activity.
Ecological or survey based methods to investigate screening uptake rates are fraught with many limitations which can be circumvented by record linkage between Census and health services datasets using variations in breast screening attendance as an exemplar.
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Although there is no question that placebo-controlled RCTs play a significant role in the evaluation of new pharmaceutical treatments, especially when it is important to rule out placebo effects, they have many inherent limitations which constrain their ability to inform medical decision making.
The RF MEMS (Radio Frequency Micro Electro Mechanical Systems) Switched Capacitor based phase shifter has highly miniaturized dimensions, and is capable of solving many limitations to which the conventional Switched Capacitors are mostly susceptible.
There were many limitations, of which the small number of participants with aHUS and the failure of five of the seven trials to recruit and to report results for atypical and typical HUS separately are of particular relevance to this work.
The main disadvantage is the fact that they cannot be used in many patients because of limitations, which have been described in detail elsewhere [ 2], and do include small tidal volume (<8 ml/kg), open chest, sustained cardiac arrhythmia and abdominal hypertension (for example laparoscopy) [ 56].
However, this algorithm has had limitations, which in many cases would preclude use in real-time tracking applications.
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