Sentence examples for many limitations such from inspiring English sources

Many limitations, such as non-Notch specificity, dose-limiting gastrointestinal toxicity and GSI resistance, have prompted an urgent need for more effective Notch signaling inhibitors for T-ALL treatment.

Clinically approved antiangiogenic anticancer agents primarily target the VEGF pathway and have many limitations, such as increased resistance, toxicity, secondary metastases, and limited efficacy in certain cancer types, highlighting the need for novel agents targeting alternative pathways.

Many limitations such as the strict dependence on beam irradiation and difficulties for wiring remain in conventional remote daylighting devices.

There are several tests to diagnose paracoccidioidomycosis, but they have many limitations such as low sensitivity, high cost, and a cross-reacting problem.

Most of the current drugs used to treat these illnesses have been used for decades and have many limitations such as the emergence of drug resistance, severe side-effects, low-to-medium drug efficacy, administration routes, cost, etc.

These manual tests can be tedious and time-consuming and have many limitations such as the inability to document the test results and the difficulty in replicating field conditions.

The traditional method is to detect by human vision, but manual surface distress survey are subject to many limitation such as non-repeatability, subjectivity, and high personal costs [4].

Nowadays, though the US machines are available with built-in speckle reduction facility, they are suffered by many practical limitations such as limited dynamic range of the display, limited number of unique directions that an US beam scan follow to average an image and limited size of transducer, etc.

In the last decades, molecular docking has emerged as an increasingly useful tool in the modern drug discovery process, but it still needs to overcome many hurdles and limitations such as how to account for protein flexibility and poor scoring function performance.

Next, it will be demonstrated that Germany has to cope with many limitations and as such has to search for alternative ways for sampling immigrants.

Despite the immense efforts directed toward their development, mAb-conjugated NPs still encounter many challenges and limitations, such as the difficulty or cost of manufacturing, immunogenicity, and penetration into tumor tissues, as mAbs are very large (150 170 kDa, 15 20 nm in diameter) and complex molecules.