Sentence examples for many ligands selective from inspiring English sources

Although the four human receptors display high extracellular sequence similarity, there exists low inter-species receptor correlation reflected by the fact that many ligands selective in rat or mice are not selective in humans [ 7].

Thus, the receptors for many ligands have not been identified.

Better efficacy with fewer side effects might be achieved with novel nicotinic ligands selective for particular nicotinic subtypes.

In Table 1 some selective H4R ligands, selective 5-HT3AR ligasds as well as compounds with affinity for both receptors are displayed.

Quirk, K. et al. [3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the α 5 subunit.

Nano-CuAl2O4 spinel Selective oxidation of benzyl alcohol to benzaldehyde [61] 18. Cu@SBA-15/amino alcohol chelate ligand Selective oxidation of benzyl alcohol to benzaldehyde [62] 19.

Lu, R. et al. Epitope-tagged receptor knock-in mice reveal that differential desensitization of α2-adrenergic responses is because of ligand-selective internalization.

Thus, our findings pinpoint how human aquaglyceroporins may be gated at the intracellular interface28, and how ligand-selective regulation may be achieved for a membrane protein.

Thus, alternative, ligand-selective recruitment and dissociation mechanisms with distinct temporal sequences are available for ER alpha action in vivo.

Together, these results suggest that the β2AR desensitization is ligand-selective.

To start with, four native co-crystallised ligands of selective and non-selective COX-2 inhibitors were identified and kept as reference template.