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Due to difficult and expensive procedures for identifying these organisms, many laboratories do not perform these assays.
34– 37 The burden of human disease due to C. gattii is probably underrecognized, as many laboratories do not undertake detailed speciation of cryptococci.
For example, NGS transcriptome data are widely used to address central biological questions in non-model species but many laboratories do not yet have the means to make the best use of these data.
Many laboratories do not participate in external quality assurance programs, and the use of a uniform method of assessment is not assured even for those that do [ 1, 3, 5, 16- 19].
Many laboratories do not have the appropriate paediatric reference ranges – an important example here is plasma testosterone concentrations in genetic (46,XY) males that change with postnatal age in the first year of life.
Indeed, a recent statement by The Endocrine Society had attempted to implement a policy toward introducing LC-MS as the diagnostic standard for publication of steroid measurements (8), although this position was later relaxed because many laboratories do not have the technology to achieve such accurate analysis (10).
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Three main errors were detected: (a) some laboratories did not use the complete reference family genetic data to report the match with the remains, (b) the identity and/or non-identity hypotheses were sometimes wrongly expressed in the likelihood ratio calculations, and (c) many laboratories did not properly evaluate the prior odds for the event.
Many hospital laboratories do not have the ability to perform this blood test and in the absence of this test the diagnosis must be made based on the clinical presentation of the patient.
20 Finally, many clinical laboratories do not correctly identify serum urate concentrations of >6.8 mg/dL as being abnormal.
Based on our previous studies in Asia, we have found that many hospital laboratories do not use anaerobic culture media.
Many clinical laboratories do not routinely test stool specimens for some enteric pathogens, including Escherichia coli O157 H7 (22 ), and do not have reliable tests for other enterohemorrhagic E. coli serotypes (23 ).
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