Exact(1)
The more pronounced effects of the antibodies compared with the genetic ablation of Nogo-A may be due to the absence of compensatory reactions, for example, upregulation of other inhibitory factors, known to occur in many KO models.
Similar(59)
In women's boxing girls are not often knocked out – certainly, there are not as many KOs as there are in men's competition.
Many KO-irradiated germ cell subpopulations were reduced when compared with the non-irradiated controls, whereas no change was found in irradiated WT testes compared with controls (Supplementary Figure S5).
Mice and ES cells from many KOs generated through this Genome 5000™ program are available through the USA NIH Mutant Mouse Regional Resource Center (https://www.mmrrc.org/catalog/overview_Major_Collection.php), Wellcome Trust (http://www.tigm.org/wellcome-trust/) and Taconic Farms (http://www.taconic.com/KO).
Many mouse KO genes have more than one paralog, consisting of a large gene family.
In contrast, we found that many RAP-KO embryos continued to develop throughout gestation.
Using Bowtie2 as the comparison engine, PAUDA runs ∼10 000 times faster than BLASTX, while assigning about one-third as many reads to KO groups.
Many ion transporter KOs result in significant developmental effects on the animals.
Many more mouse KOs have been developed and used in transporter studies in non-brain tissues (e.g. kidney).
2) I don't follow the argumentation that in dynamin1/3 KOs many of the synaptic like vesicles that form during the recovery period are not HRP labeled?
Immunofluorescence staining for the mitochondrial marker cytochrome c revealed a similar reticular pattern in many WT and Miner1 KO MEFs; however, the KO population had more cells that displayed a punctate mitochondrial pattern (Supporting Information Fig S4A).
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