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The CYP3A4 gene has many known polymorphisms, but no clinically important differences between genotypes have been observed [ 7, 8].
Similar(59)
In addition, we found many other known polymorphisms which were non-significant and non-pathogenic so were excluded from our analysis.
Although many pathological mutations have been identified [17], [18], the number of such variants is small compared to the number of known polymorphisms, and it is still unclear which polymorphisms have biological effects.
Annotated variants were filtered to exclude known polymorphisms, leaving a total of 1711 novel variants.
Newly identified polymorphisms are in bold and underlined (known polymorphisms http://www.ensembl.org).org
In addition, 1 new and 4 known polymorphisms were observed.
There are several known polymorphisms on genes involved in NER.
This sampling preceded the comparison with known polymorphisms.
CYP2D6 has several known polymorphisms that influence drug metabolism.
Neutral mutations and known polymorphisms were not counted as mutations.
At α ≤ 10-3, 11% of known polymorphism were excluded.
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