Sentence examples for many key proteins from inspiring English sources

Casein kinase 1 delta (CK1δ) phosphorylates many key proteins playing important roles in such biological processes as cell growth, differentiation, apoptosis, circadian rhythm and vesicle transport.

For example, miRNAs regulate many key proteins in the signaling pathways of colorectal cancer, e.g. the miR-106b family reduces p21 expression and affects cell cycle progression [21] [23].

Many key proteins involved in malignancy are translationally controlled, including the potent angiogenic factors VEGF and FGF-2, the oncogenes cyclin D1 and c-myc, the antiapoptotic proteins of the Bcl family, as well as the inhibitor of apoptosis protein survivin (refs. 30, 31; see ref. 1 for a more extensive list of translationally controlled proteins involved in malignancy).

Many key proteins in the cell are interaction hubs and form complexes with many different partners.

Caspase-3 was activated by the complex and then cleaved many key proteins in apoptosis.

Many different processes are involved in carcinogenesis, involving many key proteins.

The exponential growth of molecular studies, heavily driven by RNA knockdown technology, now reveals an outline of how many key protein players in genome stability and cancer biology perform their interwoven tasks, e.g. ATM, ATR, DNA-PK, Chk1, Chk2, PARP1/2/3, 53BP1, BRCA1, BRCA2, BLM, RAD51, and the MRE11 RAD50 NBS1 complex.

Among these effector caspases, caspase-3 plays a central role in the execution phase of both the intrinsic (the mitochondrial) and extrinsic (the death receptor) pathways of apoptosis by cleaving many key cellular proteins, such as poly (ADP ribose) polymerase (PARP), inhibitor of caspase-activated DNase (ICAD), and various other proteins [ 19].

It is increasingly recognized that the activity of many key regulatory proteins may be modified by S-nitrosylation (SNO), a nitric oxide-driven, posttranslational modification that converts a protein Cys thiol to an S-nitrosothiol.

In our earlier work this method was tested on a set of microarray gene expression data from psoriatic patients where it was able to correctly identify many key regulatory proteins whose relation to the disease is confirmed by independent studies [24].

Recent studies have shown that 14-3-3ζ 14-3-3ζ 14-3-3ζmany key cellular proteinteractsare involved in tumor development and progression.