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We chose to focus on kinases as they regulate many key physiological processes and have the potential to rapidly translate to therapeutic targets thanks to the existence of readily available inhibitors.
Actin filament dynamics govern many key physiological processes from cell motility to tissue morphogenesis.
Glutamate is an important amino acid involved in many key physiological processes including cell metabolism, pain sensitisation and collagen synthesis [ 11, 12].
Potassium channels regulate many key physiological processes, including neurotransmitter release, immune response, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction and cell proliferation [ 2– 4].
Filopodia, which are finger-like projections supported by tightly parallel-bundled filamentous actin, are involved in many key physiological and pathological processes, whereas abundant filopodia are considered strongly correlated with the enhanced cell migration and tumor metastasis.
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In many organs, tubular epithelia perform key physiological functions.
CoSMoS, the principled design framework used in the development of ARTIMMUS, for example, shares many key features with the methods for physiological model qualification in drug discovery proposed by Friedrich and Savic.
Evolutionarily conserved uORFs have been identified in transcripts of many key regulatory genes 30, 31, implying an important physiological role for these uORFs.
However, they may also miss many key features because in vivo intercellular interactions or 3-dimensional complex structures with physiological significance are difficult to reproduce correctly in a Petri dish.
Maintenance of pHi within a narrow physiological range is a fundamental property of almost every cell, since many key cellular processes are highly sensitive to pH [1] [3].
But many key questions remain unanswered.
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