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GSTs exist in many isoforms in plants and are active in cellular detoxification processes, in which the different isoforms are specific for different substrates [ 35].
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Single nucleotide polymorphisms (SNPs) affect the MHC sequence of many isoforms expressed in striated muscle, smooth muscle, and non-muscle tissue.
Alkaline phosphatase (ALP), a glycoprotein attached to the outer cell membrane by a glycosylphosphatidylinositol (GPI) anchor [ 48], exists as several isoenzymes and many isoforms present in tissues and serum.
In addition, isoform-based approaches increase the complexity of studying splicing regulation when many isoforms are present in the sample.
It is known that fibronectin is present in biological samples in many isoforms [ 31].
Prostate specific antigen (PSA) present in human seminal fluid exists in many isoforms due to different sequence, glycosylation pattern and polypeptide length.
Although, data on enzyme kinetics for many isoforms (including those expressed in the platelet) are available, no data on enzyme concentration in human platelets for any isoform are currently accessible.
The fact that there are many isoforms of ALDH encoded in human genome reflects the importance of these genes.
In animals and plants, miRNAs exist as multigene families [37], therefore, it was not surprising to get so many isoforms for these families in the study.
Since CD44 exists in many isoforms and is extensively spliced [53], MARCH-VIII dependent down-regulation might be variant-specific.
LAP2 exists in many isoforms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com