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Among these PPIs, many interaction pairs of two-component signal transducers were detected as reliable interactions (Fig. 3).
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They found that twice as many genetic interaction pairs can be assigned to compensatory pathways.
Among the identified interaction pairs, many have not been previously identified, even in Arabidopsis.
The result indicates that many of our predictive protein-protein interaction pairs are conserved in other organisms.
Comprehensive analysis of pairwise SYNZIP interactions revealed many interesting network patterns, such as orthogonal interaction pairs and hub-spoke motifs.
There are many interactions between any pair of biological species; if two species compete for limited resources or one of the species preys upon the other, then one of the species is extinct.
In many applications, where the goal is to find a set of candidate interaction pairs for further conformational studies, only the gene pairs identified at low FPR levels are relevant.
These conserved interaction pairs across species, referred to as interlogs, are at the conceptual center of many comparative studies [ 18, 26- 28].
Finally, high scoring compound protein pairs are predicted as candidates for interaction pairs.
The final result was high-quality interactomes consisting entirely of experimentally verified, direct, binary interaction pairs.
Calibration of the CSILRR screen conditions on ligand-dependent (FLS2 BAK1) and ligand-independent (BAK1 BIR4) interaction pairs.
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