Sentence examples for many insertion sites from inspiring English sources
The reverse transcriptase machinery is not robust: whereas the short Alu sequences of about 300 bps can be entirely transcribed, full L1s are much longer (up to about 6,000 bps) and thus are 5′ truncated at many insertion sites.
However, as with earlier laboratory based approaches (e.g. inverse PCR), the multi-copy arrays that are characteristic of many insertion sites contribute to a low signal to noise ratio in the resulting data, which in turn necessitates high coverage.
Here, we show the dynamic nature of IS 6100-mediated pathway assembly, with many different insertion sites around the lin genes.
Analysis of sequencing reads around several TE insertion sites revealed that many were inserted in just one of the haplotypes and that the other haplotype was apparently intact.
The diversity of insertion sites produces many opportunities for adaptive modulations in gene expression.
In all cases, breseq was unable to identify any mobile element insertions, including no structural variation at the known ISAba1 insertion sites, although many other types of structural variation were detected.
Using the IS element sequences we tried to identify the insertion sites and in many cases were able to create target site sequence logos using WebLogo 3 [ 33] on the basis of the direct repeats flanking the IS elements (Additional file 1: Figure S2).
In F11, there are 17 copies; however many of these differ from H37Rv and represent new insertion sites.
For transposable elements, however, new insertion sites were found scattered throughout the genome at many unlinked sites [ 28, 31, 40].
Many regions that are tagged in multiple independent tumors (termed Common Insertion Sites or Common Integration Sites or CISs) have been identified in previous studies (compiled in the RTCGD, http://rtcgd.abcc.ncifcrf.gov/, (Akagi et al., 2004)).
The low level of polymorphism observed among Ty1 occupied loci and the large number of loci common to many strains may therefore result here from the saturation of the Ty1 insertion sites rather than from the presence of fixed insertions.
