Sentence examples for many inflammatory genes from inspiring English sources
Consequently, the activation of many inflammatory genes was reduced in the lungs as well as the concentrations of various cyto/chemokines (MCP-1, VCAM-1, IL6, …).
In global transcriptional profiling analyses, OPN is one of many inflammatory genes over-expressed in adipose tissue from humans [20] and five different mouse models of obesity [36].
Although several other TFs belonging to the AP-1 and CREB/ATF families and their heterodimeric complexes, i.e., ATF3, CREB, CREBATF, CRE-BP1, and CRE-BP1-c-JUN, all of which are known to regulate the transduction of many inflammatory genes, were subsequently activated at 24 hrs, the activation of IRF-7 did not occur until 48 hrs p.i. (Figure 3).
They demonstrated that many inflammatory genes and pathways were shared across RA and SpA.
Ultimately, induction of many inflammatory genes takes place in a nuclear factor κB (NFκB dependent manner.
TRX protects cells from apoptosis [ 8] and controls many inflammatory genes through redox regulation of transcription factors [ 9].
The promoters of many inflammatory response genes, especially those encoding cytokines and chemokines, have functional AP-1 binding sites [ 6].
Indeed, a major mechanism by which IL-17 influences the expression of many inflammatory mediator genes is by stabilizing their mRNAs.
The degradation of IκBs facilitates the migration of NF-κB into the nucleus, where they typically form homodimers or heterodimers that bind to the promoters of many inflammatory response genes and activate transcription [ 14, 15].
Nevertheless, the trend of early activation coupled with late repression, which has been observed in the expression of many hepatic inflammatory genes when HF diets are compared to chow diet, can also be found in the expression of NF-κB-related plasma inflammatory proteins.
Genetic and pharmacological inhibition of ATF6 significantly suppresses NF-κB activation, which can transcriptionally regulate many other inflammatory genes.
