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18 19 Our study shows that CT scans during childhood and adolescence are followed by an increase in cancer incidence for all cancers combined and for many individual types of cancer.

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The majority of commensal isolates represented many individual MLST types but belonging to the major clonal complexes of animal and human colonizing strain types (CC5, CC22/36, CC1).

While evidenced-based guidelines promote glycated hemoglobin (HbA1c) targets <7.0% in order to reduce the long-term risk of diabetic complications, many individuals with type 2 diabetes do not achieve these targets.

Many individuals with type 1 diabetes report hypoglycemia-related driving events.

The dawn and extended dawn phenomena are both weak links in the management of many individuals with type 2 diabetes (11).

Despite recent advances in insulin delivery and home blood glucose monitoring, many individuals with type 1 diabetes fail to achieve recommended A1C target levels (1, 2).

Despite advances in insulin preparations, insulin delivery devices, and glucose monitoring technology, glycemic control in many individuals with type 1 diabetes remains suboptimal.

Here, we show that TGF-beta1 upregulates PED/PEA-15 and may contribute to the increased PED/PEA-15 expression described in many individuals with type 2 diabetes.

Our primary automated database case definition focused on diabetes treated with pharmacotherapy, an important clinical consideration given that many individuals with type 2 diabetes will be treated with lifestyle interventions alone [ 35].

Although carbohydrate counting is universally promoted in routine practice, many individuals with type 1 diabetes continue to report elevated postprandial blood glucose levels and remain at high levels for 2 or 3 h, particularly after the ingestion of meals with higher protein and/or fat content, such as pizza (19, 20) and other fast foods (9).

The published annotation of its genome sequence contains many individual genes for type II PKS/FAS [ 27].

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