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Additionally, targeted gene deletion is not feasible in many important pathogens and the normal definition of fungal pathogenicity cannot be applied in the case of obligate biotrophs, such as the powdery mildew fungus Blumeria graminis, which cannot be cultured away from living host plants.
The Phylum Apicomplexa is comprised of unicellular parasites including many important pathogens in humans and animals, such as Plasmodium, Babesia, Theileria, Toxoplasma, Eimeria and Cryptosporidium [16] [18].
Bluetongue virus (BTV) is the 'type' species of the genus Orbivirus within the family Reoviridae which includes many important pathogens for man and animals [37].
However, in the kinetoplastids, a group of early-branching eukaryotes including many important pathogens, transcriptional regulation is almost completely absent, raising questions about the extent of cell-cycle regulation in these organisms and the mechanisms whereby regulation is achieved.
For many important pathogens, the genes common to all strains within a species [known as the core genome] are a minority component of the entire gene pool for that species (the pan-genome) [17].
Moreover, B. subtilis undergoes a simple differentiation program and is the model to understand many important pathogens such as B. anthracis, Staphylococcus aureus and Listeria monocytogenes.
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Variants of this injector system are also used by many important animal pathogens (for example, Yersinia pestis, the plague pathogen) to deliver their virulence proteins.
As more genome sequences are published, including those of many important human pathogens, there is an expectation that GWAS will also provide insights into the evolution of pathogen virulence or drug resistance.
Proteobacteria encompass many important human pathogens such as Escherichia coli, Pseudomonas aeruginosa and others.
We study many important human pathogens, including Toxoplasma gondii, to model features conserved throughout the phylum.
Many important viral pathogens of fish are members of the family Rhabdoviridae.
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