Sentence examples for many human tumours from inspiring English sources
Aims: The signalling molecule nitric oxide (NO), produced predominantly in cancer by the enzyme inducible NO synthase (iNOS), has been implicated in the pathophysiology of many human tumours.
Similarly, FA β-oxidation enzymes, particularly carnitine palmitoyltransferase 1 isoforms, were also overexpressed in many human tumours [80], with the upregulation of the FA biosynthesis beginning at early stages in the cancer process in various types of cancers [77].
Increased ligand-induced EGFR activation is a frequent driving force in carcinoma progression, and in many human tumours, excessive shedding of one or more EGFR-ligands appears to be a key contributing factor [10], [25].
In the case of the L1 cell adhesion molecule (L1CAM), which is expressed in many human tumours and often linked to bad prognosis, alternative splicing results in a full-length form (FL-L1CAM) and a splice variant lacking exons 2 and 27 (SV-L1CAM).
Recent studies have demonstrated that many human tumours are hypoxic.
An upregulation of uPA and/or uPAR has been described for many human tumours.
In addition to being constitutively activated, STAT3 and STAT5 are required for malignant transformation of many human tumour types.
Studies have shown that the VEGF family plays a central role in many human tumour types (for review [ 81]).
Consistent with this hypothesis, many human tumour-associated p53 mutants possess a number of properties absent from the wild-type protein [ 3].
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated in response to growth factors and cytokines, and which contributes to the regulation of cell proliferation, apoptosis, and motility in many human tumour types.
The notion that the BRAF gene is mutated – with variable frequencies – in many human tumour types dates back to 2002 and, since then, a panel of somatic missense mutations resulting in different levels of constitutive biochemical activity has been described (Arkenau et al, 2011; Dhomen and Marais, 2007).
