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Replication errors are synonymous with division, and somatic molecular clocks that count these errors potentially facilitate the systematic reconstruction of many human tissue genealogies, allowing a fundamental distinction between old and new cells within the same individual.
Tremendous international effort such as the genotype-tissue expression project (GTEx) has been devoted to characterizing tissue-specific gene expression in many human tissue and cell types (2, 3).
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The technology of tissue engineering is being applied to (re generate many human tissues and organs.
Many human tissues are comprised of multilayered tissue structures in which spatial organization is essential to provide biological tissue functions.
Mesenchymal stem cells are present in many human tissues and serve as a readily available source of undifferentiated cells being capable to form specific tissues like bone, cartilage, fat, muscle and tendon.
TXNDC12 has also been shown to be expressed in many human tissues including skeletal muscle [25].
The ABCG1 gene is expressed in many human tissues [23], but apparently not in a muscle specific manner.
ThTP levels are relatively high in many human tissues, as a result of low expression of the 25-kDa ThTPase.
This is consistent with [12] who computed a gene co-expression network across many human tissues and reported an over-representation of positive associations.
While interpreting these results, it should be also taken into account that many human tissues have a complex architecture, as they consist of a certain number of specialized cells with variant transcriptional profiles.
An interesting new finding is that ThTP is found in many human tissues at a concentration higher than in other mammalian species, and this is likely due to a lower expression of the specific 25-kDa ThTPase.
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