This is potentially important because this receptor's activation can lead to changes in gene expression that adversely affect many human cellular processes.
The dysregulation of miRNAs and long ncRNAs is extensively involved in many human disease processes, including tumourigenesis (Matouk et al, 2007; Mercer et al, 2009; Wilusz et al, 2009; Gupta et al, 2010).
Considering that 30-50% of all known enzyme activities are not associated with genes [ 22- 24] and over 50% of all genes in higher organisms are not associated with protein function [ 25], it appears that many human biological processes have yet to be discovered.
Defects in this machinery underlie many human diseases and aging processes.
The liver plays a central role in many human-specific biological processes and mice with humanized livers can be used to model human metabolism, liver injury, gene regulation, drug toxicity, and hepatotropic infections.
These results document an important role for LRH-1 in hepatic metabolism through acting predominantly at proximal promoter sites and working in concert with additional nuclear receptors that bind to neighboring sites Nuclear receptors are signal-regulated transcription factors that control a wide range of biological processes and influence many human diseases [ 1].
Understanding serpinopathies also provides insights on protein misfolding in general, a process common to many human diseases, such as Alzheimer's and Creutzfeldt-Jakob disease.
Many human diseases result from alterations in multiple cellular processes.
MicroRNAs (miRNAs) are nucleic acid regulators of many human mRNAs, and are associated with many tumorigenic processes.
Investigating a highly complex cognitive process, like software design, involves many human factors and context-dependent variables.
