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Protein carbonyls are the most commonly used markers of protein oxidation and have been reported in many human pathologies [39, 40].
Aging is a major risk factor for many human pathologies, including cancer, diabetes, cardiovascular disorders and neurodegenerative diseases (Lopez-Otin et al., 2013).
Substrate ubiquitylation is a reversible process critical to cellular homeostasis that is often dysregulated in many human pathologies including cancer and neurodegeneration.
The increasing awareness that ciliogenesis defects underlie many human pathologies has further increased the desire to fully characterize the structure and function of these fascinating organelles [19].
Mitochondrial dysfunction is consequently linked to many human pathologies (cancer, diabetes, neurodegeneration, stroke) and apoptosis.
Programmed cell death (PCD) is an important cellular mechanism whose dysregulation is involved in many human pathologies, especially tumor formation.
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This common design principle is significant for two reasons: first, many human kidney pathologies involve filtrate flow (see below); and second, the excretory systems of existing invertebrate model systems do not recapitulate this critical aspect.
Amyloid formation is a universal behavior of proteins central to many important human pathologies and industrial processes.
Oxidative stress resulting from an imbalance between the excessive production of reactive oxygen species (ROS) and limited action of antioxidant defences is implicated in the development of many important human pathologies including atherosclerosis, hypertension, inflammation, cancer, Parkinson, and Alzheimer diseases [ 21].
Finally, the importance of proper regulation of the Notch and Wnt pathways is highlighted by aberrant Notch and Wnt signalling being linked to various human pathologies, including many cancers.
There are many entities in human pathology with hepatic iron overload.
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many retinal pathologies
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