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Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors.
Cyclo-oxygenase type-2 (COX-2) is overexpressed in many human malignant tumours and has been linked to the processes of carcinogenesis, cell survival, invasion and metastasis.
It is noted that folic acid, as an effective target ligand [25, 26], shows high binding affinity with folate receptor, which over-expressed on the membranes of many human malignant cells, but limited on the normal cells.
CD9 and CD82, members of the tetraspanin family, act as metastasis suppressors in many human malignant tumors, but the role of these molecules is not well known in clear cell renal cell carcinoma (CCRCC).
Pure active compounds from Salinispora tropica had been previously identified and exhibited inhibitory effects in many human malignant cell types [16], [17], [18], [19].
This may reflect the fact that HSF1 possesses basal transcriptional activity in many human malignant cells lines and is required for survival in these cells [1], [2], [48].
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These microRNAs play an important role in the development of many types of human malignant tumors.
These miRNAs play an important role in the development of many types of human malignant tumors.
Interestingly, NDRG2 has been found to be deregulated in many kinds of human malignant tumors [ 7- 17].
In fact, it has been shown that many types of human malignant cells, but not normal human cells, are growth inhibited by extracts of N. oleander.
SPARC is highly expressed in reactive fibroblasts, and expression is deregulated in many types of human malignant tumours (Porte et al, 1995; Le Bail et al, 1999; Rempel et al, 1999; Paley et al, 2000).
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