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Many human breast and colon cancers display elevated levels of the Src protein, and Src plays a variety of roles at different stages of tumor progression.
Many human breast cancers express AR.
Moreover, we show reduced Perp expression in many human breast cancer cell lines compared with untransformed cells.
Limb Heart Bud, an important embryonic patterning gene, is upregulated in MMTV-Wnt tumors and many human breast cancers.
Overexpression of the tyrosine kinase HER2/neu is observed in many human breast cancers and is positively correlated with enhanced tumorigenesis [ 1].
The ErbB2 receptor tyrosine kinase is overexpressed in many human breast tumors, a phenomenon correlating with more aggressive tumor characterisitcs and a worse patient prognosis.
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As with many human diseases, breast cancer patients may acquire chemoresistance to their drug therapies.
Thus, perhaps not surprisingly, many human diseases from breast cancer, Fanconi anemia, Xeroderma pigmentosum to Parkinson's disease are caused by malfunctions of the pathway.
Beclin 1, the essential autophagy regulator, is monoallelically deleted in many human ovarian, breast, and prostate cancers, and targeted mutant mice with heterozygous disruption of beclin 1 are more prone to the development of spontaneous tumors [ 26].
DDX21 expression is high in many primary human breast tumors [ 19] (and herein) and established breast cancer cell lines.
D-type Cyclins are upregulated in many human malignancies including breast cancer to promote an uncontrolled proliferation of cancer cells.
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CEO of Professional Science Editing for Scientists @ prosciediting.com