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Virus infection activates transcription and translation of many host genes.
Many host genes and proteins responding to WSSV infection were also identified through large scale approaches [ 3– 7].
As discussed later in more detail, many host genes that are required for phagocytosis have been identified using Drosophila in a series of genome-scale cell-based screens.
The TLRs have been shown to be involved in the activation of many host genes, including cytokines, chemokines and antimicrobial peptides such as β-defensin 2 [ 12- 14].
Thus, even though many host genes have been accrued by the phage kingdom as a whole, the vast majority of POGs are phylogenetic characters that are robust against repeated phage-host gene exchange, and may be useful phylogenetic markers.
Our study shows that compared to the wild type, infection of mouse brains by the mutant strain leads to significant up-regulation of many host genes involved in host protective immune response.
Similar(54)
Many host gene expression levels are not good surrogates [ 63, 74- 76].
Based on this analysis, WRKY33 appears to have a prominent repressive role on the transcription of many specific host genes indicating a negative regulatory function of WRKY33 in mediating immunity to this pathogen.
The largest category is that of genes of unknown function (20 genes), but many host response modifiers or host-range genes (16 genes) were also found.
Over half of the 89 miRNAs (65%) are intragenic; interestingly, many of the host genes have reported roles in cancer.
As intronic miRNAs may share common promoters as their host genes, many intronic miRNAs show significantly correlated expression profiles with their host genes[ 50, 51].
Related(20)
diverse host genes
several host genes
many host factors
multiple host genes
many host trees
many host institutions
many host countries
many host miRNAs
many host systems
many host domains
many host governments
many host signs
many host reactions
many sleep genes
many host locations
many candidate genes
many host niches
many host nations
many host plants
many host proteins
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