Many histone modifications, including acetylation, phosphorylation, ubiquitination, sumoylation, and methylation, are known to regulate chromatin structure and gene expression [1], [2].
Many histone modifications are stable or only partially diminished throughout mitosis.
Many histone modifications have been reported to be highly related with gene transcription.
In mammals, many histone modifications and other chromatin changes cooperate to establish and maintain the silent state.
On the other hand, many histone modifications are diffuse and occupy large regions, ranging from thousands to several millions of base pairs.
Results: We present NucHunter, an algorithm that uses the data from ChIP-seq experiments directed against many histone modifications to infer positioned nucleosomes.
Whereas correlations between many histone modifications and various chromatin states are well established, the function of these marks is an area of continued debate.
Moreover, the presence of many histone modifications, previously identified in diverse eukaryotes, was recently confirmed in the honey bee (Dickman et al. 2013).
A number of chromatin remodeling proteins associate with the inactive X chromosome resulting in the acquisition of many histone modifications characteristic of heterochromatin (reviewed in [ 3]).
Many histone modifications have not yet been investigated in any detail but, at this stage, it remains possible that no histone N-terminal tail modification, nor any histone variant, nor base-J, play any major role in VSG expression control.
