Sentence examples for many histone marks from inspiring English sources

Clusters of several surrogate SNPs located within CLPTM1L and just 3' and 5' of CLPTM1L were associated with many histone marks and open chromatin, and/or altered regulatory motifs and protein binding sites.

Such a nucleosome code could influence or contribute to our selection of regions in the human genome enriched/depleted for many histone marks in the same way as in yeast [ 47].

By combining high-resolution gene expression analysis with precise mapping of nine histone marks throughout this early stage of development, our data suggest that this reprogramming, at least in Drosophila melanogaster, occurs by transitioning through a naïve state in which many histone marks commonly present in somatic cells are absent or at comparably low levels.

Subsequent changes in histone modification pattern are observed as the germline develops and produces gametes, with dramatic increases in many histone activation marks (reviewed by Van Wynsberghe and Maine 2013).

Indeed, the direct effect of H3K36me3 on transcription is complex, as has been found for many other histone marks.

Besides H3K4me2, many other histone marks as well as epigenetic events such as DNA-methylation are also involved and more insight about the differentiation process can be gained with more data available.

In addition, the low activity of many isolated histone mark writers precludes complete modification.

Considering that many post-translational histone marks are reversible in nature, epigenetic mechanisms may also play a critical role in the process of induced HSV-1 reactivation.

As shown in our results, many of these enhancers display activating histone marks only after differentiation has occurred.

By contrast, some histone marks can span many thousands or even millions of base pairs, so the total portion of genuine signal is greater in these cases.

This leads to histone acetylation and nucleosome remodeling around ZLD binding sites, which facilitates binding by other transcription factors, and in many other cases leads to additional deposition of histone marks including H3K4me1 while at the same time prevents local deposition of repressive histone mark H3K27me3 and presumably formation of repressive higher order chromatin structure.