Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation.
Genes encoding PARG proteins have not been found in archaeal genomes, but many archaeal genomes encode other macrodomain proteins.
Large bacterial genomes encode many transcription factors, whereas many of the smallest genomes encode none (Minezaki et al. 2005).
The complex linear organisation [ 1] of many metazoan genomes encodes regulatory sequences that can be categorised into two major groups: enhancers and silencers.
Because eukaryote genomes encode many AAA+ proteins whose ATPase domains share many invariant positions, the finding of proteins similar to PSMC/Rpt ATPases did not necessarily imply that they were true orthologs.
The potential for vast post-transcriptional control exists: mammalian mRNAs contain extensive untranslated regions and their genomes encode many hundreds of RNA binding proteins and non-coding RNAs.
Our human microbial genomes encode many metabolic capacities that we have not fully evolved.
Plant genomes encode many RGA genes, and some of these genes are transcriptionally activated in the plant's defence against pathogens [ 42, 46, 69– 73].
Nevertheless, recent bioinformatic analyses of prokaryotic proteomes have revealed that bacterial and archaeal genomes encode many proteins containing glutamine- and asparagine-rich prion-like domains resembling those found in most confirmed and putative S. cerevisiae prions (Alberti et al., 2009; Espinosa Angarica et al., 2013; Yuan et al., unpublished data).
M. abscessus genomes encode many proteins potentially involved in drug-efflux systems, including members of the major facilitator family, ABC transporters and MmpL proteins; Small Multidrug Resistance-family, a family of lipophilic drug efflux proteins [ 45]; and a multidrug resistance stp protein similar to M. tuberculosis involved in spectinomycin and tetracycline resistance [ 46].
