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These abnormal cancer cells have many genetic abnormalities that cause them to grow excessively.
That is probably because cancer cells have so many genetic abnormalities.
While the normal female has 44 autosomes plus two X-chromosomes (female) and the normal male 44 autosomes plus one X-chromosome and one Y-chromosome (male), many genetic abnormalities are possible.
It is further evident that many genetic abnormalities underlying tumor progression are probably phenotypically silent.
Although many genetic abnormalities are associated with clinical outcome, only few of them are routinely used for treatment stratification.
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Scientists believe that lupus is rooted in many subtle genetic abnormalities.
Although insulin resistance itself is still poorly understood, there is evidence that the levels of expression of IRS-3 and PI-3 kinase are reduced, although there may be many other genetic abnormalities involved.
Based on these techniques, many different recurrent genetic abnormalities have been identified in metastatic CRC which frequently include gains of chromosomes 8q, 13q and 20q [8], [8] together with losses of the 1p, 8p, 17p and 18q chromosomal regions [9].
The approach will be broadly applicable for many types of genetic abnormalities, and should reveal numerous, previously unrecognized, mRNA splicing mutations in exome and complete genome sequences.
So far, many genetic and non-genetic abnormalities have been linked to mitochondrial dysfunction [ 3].
Because the fruit fly's life cycle is so short and they reproduce so fast (sexually maturity is reached within eight days of hatching), drosophila are ideal subjects for the study of inherited traits, including genetic abnormalities, over many generations.
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