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Submergence tolerance was initially considered a complex trait involving many genes located in multiple quantitative trait loci (QTL) (Mackill, Ismail, Singh, Labios, and Paris, 2012).
The specific genetic element/s in 17q responsible for the cancer-promoting effect of these aberrancies is yet to be defined although many genes located in 17q have been proposed to play a role in malignancy.
However, many genes located in the previously identified high-SNP segments showed exceptionally high Ks-values (Ks > 0.05).
The expression of most Hsa21 genes and of many genes located on other chromosomes were dysregulated in the heart of trisomic fetuses at 18 22 weeks of gestation.
By investigating the fractionated genes in the B. rapa genome, it was found that genes were lost individually rather than via the simultaneously deletion of many genes located in a large fragment.
This indicates that the additive, dominance, and imprinting variance of number of teats, backfat and lifetime daily gain in these populations is explained by many genes located throughout the genome, rather than by a few mutations with large effects.
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Recent data indicate that many miRNA genes located within introns of host genes have their own promoters [ 36].
As a result many structural genes located in these regions are divergently orientated in CP21 and CP220/CPt10 (Fig. 4).
The absence of an important class of stress-related transcription factors can lead to modifications in the expression of many other genes located overall the genome.
However, SNPs located in intronic and intergenic regions can regulate the expression of many other genes (located on the same chromosome or different chromosomes); serving as master regulators and this may be how our intergenic and remaining intronic variants can be altering paclitaxel response [ 30].
The role of many of the genes located on the sex chromosomes is unknown.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com