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Many genes implicated thus far, which are involved in chromatin remodelling, metabolism, mRNA translation and synaptic function, seem to converge in common pathways or genetic networks affecting neuronal and synaptic homeostasis16.
In a review article, Shao-Cong Sun and colleagues from the University of Texas MD Anderson Cancer Center in Houston, USA, discuss how the family of transcription factors that make up the nuclear factor-κB (NF-κB) pathway mediate the expression of many genes implicated in different processes of the body's immune and inflammatory responses.
Rlm1 induces expression of many genes implicated in cell wall biogenesis [49].
Many genes implicated in ASD are of known function, while for other genes a role in brain function is yet to be identified.
This subset includes two Cu-Zn superoxide dismutases (SOD), a peroxidase, two HslJ-like heat shock proteins, and many genes implicated in antibiotic resistance (Table S5).
Moreover, the mRNA levels of many genes implicated in survival/apoptotic decision displayed modulated levels of expression by H19 knockdown in hypoxic stress.
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Galbán et al (2008) found that, PTBP2 and HUR jointly promoted the translation of hypoxia-inducible factor 1 α (HIF-1 α), and HIF-1 α regulated many cancer-related genes, such as vascular endothelial growth factor, β-catenin, and many other genes implicated in cellular functions, such as proliferation, angiogenesis, and survival (Wenger et al, 2005).
The NF-kB transcription factor promotes the expression of many different genes implicated in the antiviral response.
TGF-β1 also activates many target genes implicated in wound healing and ECM production including connective tissue growth factor (CTGF) and fibronectin, which were both shown to be expressed in salamander regenerating tissues [15], [28], [37].
For instance, by performing a genome-wide RNAi screen in Drosophila S2 cells, Kwon et al. [16] found many different genes implicated in a variety of cellular processes, including spindle pole organization, cell shape and polarity, and cell adhesion, to be involved in centrosome clustering.
Differentially methylated loci (DML) involve many key genes implicated in inflammation, immune responses, cell-cell interactions, and matrix regulation.
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