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According to the results obtained by Brockmann-Gretza and Kalinowski (2006), many genes coding for branched-chain amino acid ABC transporters and nitrogen metabolism were negatively controlled by the stringent response.
PGC-1α is a transcriptional coactivator of PPARγ and regulates expression of many genes coding for mitochondrial proteins [13] [15].
Many genes coding for traits involved in reproduction (i.e. traits linked to fitness) may have a sex-specific expression.
Under the limitation of oxygen, many genes coding for oxidases, nitrate reductase and nitrite reductase were up-regulated.
Polymorphism in malaria parasite genes generated by random mutations is a frequent characteristic of many genes coding for antigens.
Many genes coding for cytoplasmic membrane, cell wall and plastid proteins showed an up-regulation in the dark phase (ZT20) (Figure 1A).
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Nonetheless, a gene dosage effect was clearly demonstrated as many genes coded on chromosome 8 were expressed at higher levels in AML with trisomy 8.
Conley (2009) points out that the phenomenon of pleiotropy presents a related challenge for the plausibility of a genetic instrument: since many genes code for proteins that may have multiple functions and effects, it is hard to know for certain that the instrument only affects outcomes through the endogenous regressor.
Recent surveys have shown that many gene coding regions in the human genome do not show an excess of low-frequency alleles, suggesting that balancing selection might be more common than previously thought (reviewed by Bamshad et al. [31]).
When using almost any given lumen protein gene as a query gene for the multi-experiment co-expression database tool, the resulting list of co-expressed genes contained many other genes coding for lumen proteins with high correlation coefficients (data not shown).
Many other genes coding for transcription factors were also down-regulated (Additional file 6) such as AP2/EREBP transcription factor (VVTU4551_at, cluster 5).
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