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Because the coding regions of many gene clusters that arose by tandem gene amplification are quite conserved, hybridization-based approaches would not be sufficient to distinguish between allelic and paralogous copies (Xu and Messing 2008).
The A. oryzae genome contains many gene clusters likely involved in biosynthesis of secondary metabolites, and these clusters are highly enriched in non-syntenic blocks (NSBs) (Machida et al. 2005, 2008; Kobayashi et al. 2007).
Although many gene clusters are conserved across species, rearrangements appear to be frequent in most lineages.
Many gene clusters conserved in green algae [ 22] are also conserved in Chlorella sp. ArM0029B.
Many gene clusters are significantly up-regulated in a glucose-grown, ccpA-mutant derivative of L. plantarum, suggesting catabolite control.
We demonstrate that cgd8_810 can putatively bind the overrepresented G-box motif, implicating this ApiAP2 in the regulation of many gene clusters.
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Many genes cluster in small, more vague interaction networks.
In an unsupervised clustering with 864 genes, many interesting gene clusters were observed, some of which had not been previously described.
Using end-enriched RNA-sequencing (Rend-seq) with single-nucleotide resolution, we found that many bacterial gene clusters encoding conserved pathways have undergone massive divergence in transcript abundance and architectures via remodeling of internal promoters and terminators.
Regional coordination of gene expression and repression is found in many imprinted gene clusters in the mammalian genome and is regulated by imprinting centers or imprinting control regions.
Furthermore, many lantibiotic gene clusters contain a GG-leader peptidase that is the N-terminal domain of an ABC-type transporter.
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