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Not many gene changes are needed in either case to complete speciation.
While many gene changes have been tied to the early stages of cancer development, this is one of only a few that have been linked to metastasis, notes Jeffrey Trent of the National Human Genome Research Institute in Bethesda, Maryland.
Although this down regulation does not persist in CsA treatment, many gene changes do persist in the CsA + peptide treatment.
Although each tissue culture-xenograft sample did cluster together there were many gene changes between the paired samples (Table 4).
In addition, as many gene changes in reciprocal as in the same direction were observed, when results from RWV and space cultures were compared [ 41].
Our data show that the AB platform had substantially higher sensitivity than the Affymetrix platform in these experiments, detecting four times as many gene changes.
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Given that expression of many genes changes when cells become malignant or are placed in different microenvironments, we asked whether these changes were accompanied by global reorganization of chromatin.
Another predicted hallmark of MOP1 activity is transcriptional silencing, and the expression pattern of many genes changes in some tissues of mop1 1 mutants.
Approximately half as many genes changed their expression when comparing ID vs. CD.
Kinetin, for example, was shown to affect splicing of other genes [24], and many genes change their expression level in IKAP-deficient cells [20], [21], [39].
Interestingly, many genes change the direction of their regulation between the early and the late phase of the time-course (Figure 1C, Figure S2, Figure S3, Figure S4 and Figure S5).
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