Many fundamental biological pathways and two signal transduction pathways were identified through KEGG pathway analysis.
As molecular coordinators, the tetraspanins are involved in many fundamental biological pathways and are correlated with the malignant process and prognosis (Lazo, 2007).
The tribbles family of proteins are being recognized as modulators of many fundamental signalling pathways, biological processes and disease pathologies [ 1, 2].
Although genomic comparison showed that in G. lamblia the contents of many fundamental biologic pathways are simplified and the whole genome is very compact, in our study 40% of its genes were identified as duplicated genes.
These structured RNA domains are widespread in bacteria and help in modulation of many fundamental biochemical pathways by sensing the metabolites such as adenine, guanine, FMN, glycine, and lysine [ 52].
The MEK/ERK and PI3K/Akt signaling pathways regulate many fundamental cellular functions, such as cell proliferation, survival and motility.
These endogenous pathways play many fundamental roles, including regulation of mRNA accumulation and translation, chromatin silencing, programmed DNA rearrangements and genome surveillance [ 4].
Rho GTPases control a wide variety of signal transduction pathways regulating many fundamental processes of cell biology, such as organization of the actin cytoskeleton [ 2], gene expression, cell proliferation and survival [ 3].
See other articles in this series, Function of the ubiquitin-proteasome pathway is essential for many fundamental cellular processes, including the regulation of receptor signaling pathways and the timely degradation of cyclins, cyclin-dependent kinases, and cyclin-dependent kinase inhibitors during mitosis.
PI3K/Akt is an important pathway in regulating many fundamental biological processes including cell proliferation, survival, apoptosis, glucose metabolism, and cell migration [ 19, 20].
