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While expression of H1R, H2R, and H4R has been described on neutrophils (Table 2), for many functional studies on the effect of histamine on neutrophils, it remains unclear whether these effects can be attributed to a direct effect of histamine on neutrophils or is mediated by effects of histamine on other cells types, for instance mast cells, which in turn affect neutrophil functions.
Given the conspicuous absence of a digestive system, many functional studies of siboglinids have concentrated on the question of nutrition.
This indicates remodelling of the t-tubular network in the failing human heart may contribute to calcium handling abnormalities seen in heart failure and underpins many functional studies in animal models.
On the latter, many functional studies are reliant on, but also limited by, the analytical resolution of Gene Ontology (GO).
Many functional studies have been conducted on miR-133a and its experimentally proven oncogene targets, suggesting its role as a tumor suppressor in various cancers [ 9, 13, 14].
The gene models and their putative functions have been automatically predicted from the genome sequence and have been used in many functional studies.
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Still the positive results of this study are large by comparison with many functional MRI studies in Parkinson's disease.
Such measurements will be of great use for many functional imaging studies, including ones underlying the motivation for the present work, namely the longitudinal monitoring of cortical plasticity during rehabilitation of patients with motor deficits [ 5, 7, 9].
Many functional neuroimaging studies have confirmed abnormalities in structures such as the hypothalamus, cingulate gyrus, prefrontal lobe, and insular lobe.
There have been many functional imaging studies that have investigated the neural correlates of speech perception by contrasting neural responses to speech and "speech-like" but unintelligible control stimuli.
It can therefore complement many functional genomics studies.
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