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Drosophila melanogaster annotations define the locations of many functional protein domains.
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Research of a past decade and a half leaves no doubt that complete understanding of protein functionality requires close consideration of the fact that many functional proteins do not have well-folded structures.
In addition to known RNA-binding motifs, we detected several protein domains previously unknown to function in RNA recognition, as well as non-annotated and/or disordered regions, suggesting that many functional protein-RNA contacts remain unexplored.
Despite recent findings that long evolutionary times are required to incorporate TE into proteins, we found many functional proteins with translated TE cassettes derived from young TEs.
Also, it is an essential constituent of bones, teeth, enzymes, and many functional proteins.
However, protein biomarker discovery is challenged by detection sensitivity and low abundance of many functional proteins involved in disease processes.
Many functional proteins involving various metabolisms were likely to be responsible for the lesion formation of spl5 mutant.
ROS generation can regulate the cell-fate decision through the control of many functional proteins.
Many functional proteins are involved in calcium binding or biomineralization--prerequisites for interacting with the mineral phase during eggshell fabrication.
However, it is well known that for many functional proteins dS is often greater than dN (i.e. purifying selection) due to strong functional and structural constraints.
The L-methionine is the first amino acid incorporated into many functional proteins during translation and also serves as a precursor for cysteine biosynthesis.
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