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The Wnt/ β-catenin signaling pathways) are composed of many functional networks, including a bundle of signaling pathways consisting of various proteins that transduce signals from the outside of a cell through the receptors on the cell surface and into the cell interior.
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Many functional network properties of the human brain have been identified during rest and task states, yet it remains unclear how the two relate.
Many functional network subunits demonstrated no statistically significant deviations from additive behavior (Fig. 9C, grey).
Many of the functional networks identified in this study were also associated with processes in connective tissue development and function.
These identified metabolites in the profiles are usually well-studied metabolites which tend to have many functional partners in the network.
LC3 homologues form many functional interactions in the autophagy network [ 35].
In contrast, if the metabolites in a pathway tend to have many functional partners in the biological network, the dysregulation signal is more likely to be alleviated.
Therefore, to optimally contextualize genes, functional networks should integrate many sources of evidence of interaction among proteins and genes.
constructed an Arabidopsis gene-expression network and identified many functional modules associated with photosynthesis, protein biosynthesis, cell cycle, defense response and others, and these modules revealed new insights into gene function organization.
The age-linked decline in many physiological processes are in fact associated with an increase in the expression of many genes that could alter specific signaling pathways by generating an imbalance in the functional networks, hence affecting key biological functions.
In recent studies, several plant gene co-expression networks have been built and many functional modules have been inferred or identified.
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