Exact(1)
The mode of action may be different between acute and preventive effects of SPG stimulation and is further underlined by the absence of an obligatory association between the two effects in individual patients, although this effect may be underestimated, as many frequency responders could not be evaluated for acute response.
Similar(59)
Furthermore, therapeutic responders were defined as patients who were either acute responders, frequency responders, or both.
5 patients were both acute and frequency responders.
Per protocol, frequency responders experienced ≥ 50% reduction in attack frequency and acute responders treated ≥ 50% of attacks.
In total, 68% of all patients were responders, 55% of chronic patients were frequency responders and 32% of all patients were acute responders.
At 12 months 55% of chronic patients were frequency responders and 32% of all patients were acute responders.
Of the 12 frequency responders, HA frequency was reduced to ≤2 HA/week in 9 subjects.
Seventeen patients (42.5%) showed at least a 50% reduction in attack frequency (responders) in Phase 2, while 7 (17.5%) showed a 25 50% reduction (semi-responders) in the same phase.
This estimate was based on the study-reported percentage of frequency reduction across the entire SPG-treated cohort (i.e., frequency responders and non-frequency-responders). The medical management cohort was assumed to maintain its baseline attack frequency.
75% (N=9) were frequency responders; frequency reduced by 90% (from 22.3 at baseline to 2.1 (range 0-8) attacks/week).
Three of the 48 frequency responders (6%) received transitional therapies between microstimulator insertion and the 12 month visit.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com