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Since they allow the transduction of many external stimuli into cell signals, they are also major actors in the responses of the cell to their environment.
This hypothesis is supported by recent evidence indicating that many external stimuli commonly identified as trigger factors may not trigger migraine attacks when systematically studied in a prospective setting.
For example, many external stimuli corresponding to gene deletions in the CB map include agents causing DNA damage and microtubule depolymerization, while the stimuli related to the ESP map mostly include agents causing protein synthesis and glycosylation inhibition (see Supplementary website).
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Naturally, progress in complexity of dynamic and functional imaging leads to multidimensional data sets containing spectral information on local physical and chemical functionalities, which can be easily expanded further to acquire data as a function of a plethora of parameters such as time, temperature, or many other external stimuli.
Although C. elegans processes many kinds of external stimuli, we focused on gentle touch stimulation.
The first committed and rate-limiting step in the mevalonate pathway for isoprenoid biosynthesis is catalysed by 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), and modulated by many endogenous and external stimuli [ 37].
Further, many prisoners report "experiencing severe and even paralyzing discomfort around other people, engage in self-imposed forms of social withdrawal, and suffer from extreme paranoia; many report hypersensitivity to external stimuli (such as noise, light, smells), as well as various kinds of cognitive dysfunction".
Many observations suggest that appropriate external stimuli can ameliorate the state of various biological entities and even rejuvenate them.
Additionally, a large proportion of upregulated DEGs were annotated with the GO term Biological Process involved in responses to external stimuli and many of these GO terms were also significantly enriched for upregulated DEGs.
The GeneChip data for Arabidopsis include many time-course experiments for external stimuli in addition to precise tissue samples collected by AtGenExpress, whereas this type of experiment may be more difficult to obtain for mammalian species.
HS are importantly implicated in the regulation of the proteins they bind, and have recently emerged as critical regulators of many events involving cell response to external stimuli.
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