Many microarray experiments provide expression values for a list of probes instead of genes.
For example, certain genetic or pharmacological perturbations can result in planarian worms with either two or no heads (Reddien and Sánchez Alvarado, 2004; Oviedo et al., 2010; Beane et al., 2011), while cutting and grafting experiments provide many examples of changes of limb morphology in insects and amphibians (Endo et al., 2000; Yakushiji et al., 2009).
Animal experiments provide equivocal results.
Additionally, such experiments provide CLE peptides at significantly higher concentrations than is found in vivo (and likely above the dissociation constants of many non-cognate receptors).
SR is the group leader, working in many arms of the project including experiments, provided scientific suggestions and criticisms for improving the database, guided in statistical analysis, conforming to ethical principles, critical examination, presentation and manuscript preparation.
In reports that contain large datasets, across many experiments, this structure provides the maximum flexibility to report data yet still affords the structure that the data model provides.
Since the Foxa1 ChIP-Seq experiment provided many more putative downstream bound regions for validation, we focused on this data set for downstream analysis.
However, like many experiments with clusters, these can either provide results consistent with the equilibrium conditions that reflect those relative stabilities, or they can give results that reflect the rates of the cluster-forming processes rather than the equilibrium characteristics, as the latter may take far longer to reach than the time required to form clusters.
DBS provided intellectual input into many experiments.
KS, MS, SS and KM provided intellectual input into many experiments.
