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Many existing ontologies can be expanded in this way with minimal effort.
The INOH database provides a set of uniquely developed ontologies designed for pathway annotation, because many existing ontologies including Gene Ontology (GO) (15) is designed for annotating gene function.
The reader more interested in detailed core theoretical foundations on which this study (and many existing ontologies such as DOLCE) is based, is referred to (among others) [ 3- 5].
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OBO-RO provides a set of common relationships used in many existing bio-ontologies.
This is the reason why many concepts are not mapped to existing ontologies, though also the lack of ontologies with a clear open license, as defined by the Open Definition [21], restrict the options.
These terms, described below, are in many cases similar to or comparable with existing terms within existing ontologies and nomenclatures.
Although this is a worthwhile longer term aim, the state of the art is that existing ontologies are not orthogonal or interoperable, and many present a focus that is unsuitable for gene expression data.
Most of existing ontologies construction tools support construction of ontological relations (e.g., taxonomy, equivalence, etc).
It was developed following the Systematic Approach for Building Ontologies (SABiO) [9], which prescribes an ontology development process comprising activities for purpose identification, ontology capture, ontology formalization, integration with existing ontologies, ontology evaluation, and ontology documentation.
Fuzzy ontology membership values can be learned from documents or users, based around existing ontologies such as the Unified Medical Language System UMLSS).
It is attractive for ontology engineers to select and reuse the existing ontologies by measuring and evaluating them because ontology construction is rather tedious and costly.
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CEO of Professional Science Editing for Scientists @ prosciediting.com