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In many eukaryotes encoding multiple CAs, different isoforms of the enzyme have been shown to be distributed in different tissues and cell compartments [3].
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Since many eukaryotes encode putative enzymes of unknown function, they may also encode a cryptic MPD that would serve in an alternative biosynthetic route to IPP (1).
Ideally such an observation would involve a single eukaryote or a small group of related eukaryotes encoding a gene from a specific bacterial lineage.
Our findings demonstrate that eukaryotes encode active CDPSs and suggest that all CDPSs have a similar aminoacyl-tRNA synthetase-like architecture and ping-pong mechanism.
Interestingly, the genomes of diverse eukaryotes encode more than one form of eIF4G.
All eukaryotes encode multiple, paralogous tubulins that evolved through a series of gene duplications at early stages of eukaryote evolution as well as many subsequent, lineage-specific duplications [ 3].
In addition, we identified a novel Hint gene family present in many eukaryote groups that encodes a VWA domain fused to a distinct Hint domain we call Vint.
MicroRNAs are small (~20 23 nucleotides) non-coding ribonucleic acid (RNA) molecules encoded in the genomes of many eukaryotes and viruses.
Finaly, one CDS had a strong homology to a Zn-metalloprotease (mpr), also carried on plasmids in several human and/or animal pathogenic bacteria or opportunistic bacteria: P. putida, Yersina pestis, Escherichia coli O157 H7, Klebsiella pneumoniae, Salmonella enterica, etc. Metalloproteases like those encoded on pRSC35 are essential for the infection process of many eukaryotes [ 43- 46].
The genes that encode the folate biosynthesis enzymes DHFR and TS are fused in many eukaryotes (Stechmann and Cavalier-Smith 2002) resulting in synthesis of a two domain multifunctional protein.
Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes.
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