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Adenosine nucleotides provide energy for many essential cellular functions.
Lectins are a widespread class of proteins implicated in many essential cellular and molecular recognition processes.
The structural organization of eukaryotic DNA in chromatin is intricately linked to the regulation of many essential cellular processes, such as genomic DNA replication and transcription8,9.
Membrane proteins (MPs) are important pharmacological targets because of their involvement in many essential cellular processes whose dysfunction can lead to a large variety of diseases.
Microtubules are implicated in many essential cellular processes such as architecture, cell division, and intracellular traffic, due to their dynamic instability.
They have a crucial role in the folding of a set of proteins involved in the regulation of many essential cellular pathways and also re-folding of stress-denatured polypeptides.
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Therapies targeting HER2 signaling, angiogenesis, DNA repair, and many other essential cellular processes that are dysregulated in cancer have produced significant improvements in disease outcome, although careful patient selection and toxicity management are required to maximize their therapeutic potential.
However, actin must be exquisitely regulated during cell migration, cell adhesion, cell division, and many other essential cellular functions.
These kinases have many other essential cellular functions and are better conserved in their contribution to timekeeping than any of the clock proteins they phosphorylate [ 6].
PCNA forms a ring around DNA to facilitate and control DNA replication, which plays a role in many other essential cellular processes, such as the maintenance of chromatin structure, chromosome segregation and other cell-cycle progression stages.
Because the Akt pathway plays vital roles in controlling many diverse essential cellular processes, it is likely that drugs would only be tolerated if they modestly inhibit the Akt-signalling network.
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