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Given the increasing reports of the development of resistance in many enzymatic systems, a drug that could be recognized by more than one enzyme could prove highly advantageous in overcoming resistance mechanisms related to binding site mutations.
We believe that this approach will have value for many enzymatic systems where access to large amounts of active enzyme is problematic.
It acts as cofactor for many enzymatic systems, and participates in crucial physiological processes including photosynthesis and respiration.
We dub such effect ultra-affinity in analogy with energy-consuming ultrasensitivity observed in many enzymatic systems (Goldbeter and Koshland, 1981).
It is well known that hydrogen peroxide is always present in the liver, which possesses many enzymatic systems that are capable of producing free radicals from phenolic or polyphenolic compounds, so that it is quite possible that the same phenomena occur in the intact perfused liver [ 37– 40].
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Natural antioxidant defense consists of many enzymatic and nonenzymatic systems that act in concert with dietary antioxidants [ 12].
Therefore, mammalian cells have developed many enzymatic and nonenzymatic antioxidative systems [ 20, 45, 46] as well as transfer proteins that sequester prooxidant metals inhibiting their participation in redox reactions (Table 1) [ 47].
Synergistic effects between those cellulases were demonstrated by many enzymatic studies.
In order to overcome oxidative stress, plants have developed two main antioxidants defense mechanisms that can be classified as non-enzymatic and enzymatic systems (Cheruth et al. [2009]).
These data suggested that other enzymatic systems could be involved in C24 degradation.
In comparison to enzymatic systems, the biomimetic catalyst was more efficient and had wider substrate specificity.
More suggestions(15)
many enzymatic characteristics
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many volcanic systems
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many optical systems
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