Sentence examples for many endogenous substrates from inspiring English sources

The transportation and distribution of many endogenous substrates like hormones, bile acids and neurotransmitters mainly depend on the activity of transporters.

They could metabolize not only many endogenous substrates such as steroid hormones, but also exogenous toxins for excretion [ 1].

Cytochromes P450 are heme-containing monooxygenases that catalyze the NADPH-dependent biotransformation of a majority of clinically used drugs and xenobiotic toxicants as well as many endogenous substrates.

The ABCC2 transporter is a transmembrane protein expressed in the apical cell membrane of hepatocytes and epithelial cells of small intestine and kidney, where it is involved in the elimination of many endogenous and exogenous substrates from the cell, including compounds clinically relevant [2].

CYP2E1 encodes an enzyme that metabolises many endogenous and exogenous substrates such as alcohols, ketones and drugs [ 24].

In the present study, this notion is supported by the down-regulated expression of several enzymes of the cytochrome P450 family, which play a central role in the oxidative metabolism of many endogenous and exogenous substrates [ 70, 71].

The greater intercellular permeability and surface fenestrae along with the lack of a prominent basement membrane between the LSEC and parenchyma all contribute to enhance hepatocyte exposure to soluble components in the circulating blood (DeLeve, 2007b; DeLeve, 2007a; Perri and Shah, 2005) and improve passive transport of many endogenous and xenobiotic substrates (Braet and Wisse, 2002).

Considering that many plant secondary metabolites are oxidized by CYP proteins and endogenous substrates controlling physiology such as hormones are also metabolized by CYP proteins, it is straightforward to access the effect of natural selection on the CYP protein diversity.

Many substrates have been identified for each exo-RNase [ 4], but no endogenous substrates have been assignment of to these enzymes based on global substrate profiling.

The ABC transporters are a superfamily of membrane transporters with diverse substrates that in eukaryotes mediate the ATP-dependent efflux of endogenous substrates, including bile acids and cholesterol, as well as of xenobiotics, including many drugs.

Many endogenous compounds can transfer through the placenta.