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Many endogenous pathways are engaged in restoring cellular homeostasis, including stabilization of unfolded proteins to prevent aggregation and removing damaged or excess proteins through proteolysis.
On the one hand FXR holds a regulative function in many endogenous pathways and on the other hand the features of its active site are well-characterized.
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These endogenous pathways play many fundamental roles, including regulation of mRNA accumulation and translation, chromatin silencing, programmed DNA rearrangements and genome surveillance [ 4].
However, they also function to regulate titers of many endogenous compounds [ 21, 24] involved in other pathways that may indicate general response to environmental stress (e.g., Cry1F toxin exposure).
Although OCTs are functionally influenced by many endogenous and exogenous substances, to date there are no data about pathways and mechanisms of the regulation of OCT expression in cancer.
We also note that the profile of HRDE-1-coIP siRNAs suggests that many endogenous protein-coding genes can be potentially targeted by germline nuclear RNAi pathway.
Many endogenous compounds can transfer through the placenta.
Flies have an Htt protein, so the endogenous pathways with which it interacts are likely conserved.
Also, the MNT molecule, like many endogenous proteins, could be subjected to intranuclear proteasomal degradation [29].
Alternatively, they may be interlinked with endogenous pathways to create artificial networks of higher complexity.
There is considerable evidence, that many endogenous mediators, drugs and toxines can induce hormesis via receptor- and cell signaling mechanisms, e.g. the PI3K, ERK1/2 and p38-pathway [ 26].
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