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"We have so many end points".
In short, as we have learned from drug exposure studies, many end points in rodents can predict adverse outcomes in humans.
Future biomonitoring studies should make an effort to combine many end points, with emphasis on adducts, mutations, and constitutional metabolic factors.
Such data are required not only to evaluate any given model, but also to determine how many end points and/or models are necessary for predictive validity.
Steroidogenesis and the hypothalamic-pituitary-gonadal axis appear to be important loci of phytoestrogen actions, but these inferences must be tentative because good dose-response data are not available for many end points.
For TCE, understanding metabolism is particularly important because, as discussed below, for many end points of observed toxicity, the active agent(s) is thought to be a metabolite(s) rather than the parent compound.
Similar(48)
The outcomes we examined are arguably few of many end-points that a study such as this may address.
For the cancers breast cancer, colon cancer, and prostate cancer were chosen as candidates for further study, as these cancers are frequent (many end-points could be expected, especially in the older age strata).
Another conclusion of this research was that introducing patchy or modular connectivity, with occasional long-range connections that have many end-point connections to a patch or module, was much more efficient than random (but sparse) connectivity, especially for large brains.
Second, many study end points were captured by patient report.
Many toxicological end points were investigated, but only minimal responses were observed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com